Arias, H.R., Jin, X-T., Gallino, S., Peng, C., Feuerbach, D., Garcia-Colunga, J., Elgoyhen, A.B., Drenan, R.M., and Ortells, M.O. (2019) Selectivity of (+/-)-citalopram at nicotinic acetylcholine receptors and different inhibitory mechanisms between habenular a3b4* and a9a10 subtypes. Neurochemistry International 131:104552

Arvin, M.C., Jin, X-T., Yan, Y., Wang, Y., Ramsey, M.D., Kim, V.J., Beckley, N.A., Henry, B.A., and *Drenan, R.M. (2019) Chronic nicotine exposure alters the neurophysiology of habenulo-interpeduncular circuitry. Journal of Neuroscience 39(22): 4268-4281 *corresponding author

Arvin, M.C., Wokosin, D.L., Banala, S., Lavis, L.D., *Drenan, R.M. (2019) Probing nicotinic acetylcholine receptor function in mouse brain slices via laser flash photolysis of photoactivatable nicotine. Journal of Visualized Experiments 143: e58873 *corresponding author

Peng, C., Yan, Y., Kim, V.J., Engle, S.E., Berry, J.N., McIntosh, J.M., Neve, R.L., and *Drenan, R.M. (2019) Gene editing vectors for studying nicotinic acetylcholine receptors in cholinergic transmission. Eur. J. Neurosci. 50(3): 2224-2238 *corresponding author


Yan, Y., Peng, C., Arvin, M.C., Jin, X-T., Kim, V.J., Ramsey, M.D., Wang. Y., Banala, S., Wokosin, D.L., McIntosh, J.M., Lavis, L.D., and *Drenan, R.M. (2018) Nicotinic cholinergic receptors in VTA glutamate neurons modulate excitatory transmission. Cell Reports 23: 2236-44 *corresponding author

#Banala, S., #Arvin, M.C., Bannon, N.M., Jin, X-T., Macklin, J.J., Wang, Y., Peng. C., Zhao, G., Marshall, J.J., Gee, K.G., Wokosin, D.L., Kim. V.J., McIntosh, J.M., Contractor, A., Lester, H.A., Kozorovitskiy, Y., *Drenan, R.M., and *Lavis, L.D. (2018) Photoactivatable drugs for nicotinic optopharmacology. Nature Methods 15(5): 347-50 #equal contribution, *co-corresponding author


Parker, R.L., O’Neill, H.C., Henley, B., Steele, A.D., Perez, X.A., Wageman, C.R., Drenan, R.M., Marks, M.J., Miwa, J.M., Grady, S.R., and Lester, H.A. (2017) Deletion of lynx1 reduces the function of a6* nicotinic receptors. PLoS One 12(12): e0188715.

Arias, H.R., Jin, X-T., Feuerbach, D., and Drenan, R.M. (2017) Selectivity of coronaridine congeners at nicotinic acetylcholine receptors and inhibitory activity on mouse medial habenula. Int. J. Biochem. Cell Biol. 92:202-209

Peng, C., Engle, S.E., Yan, Y., Weera, M.M., Berry, J.N., Arvin, M.C., Zhao, G., McIntosh, J.M., Chester, J.A., and *Drenan, R.M. (2017) Altered nicotine reward-associated behavior following a4 nAChR subunit deletion in ventral midbrain. PLoS One 12(7): e0182142. *corresponding author

Hurtado-Zavala, J.I., Ramachandran, B., Ahmed, S., Halder, R., Bolleyer, C., Awasthi, A., Stahlberg, M., Wagener, R.J., Anderson, K., Drenan, R.M., Lester, H.A., Miwa, J.M., Staiger, J.F., Fischer, A., and Dean, C. (2017) TRPV1 regulates excitatory innervation of OLM neurons in the hippocampus. Nature Communications 8: 15878.

Lee, H.J., Zhang, D., Jiang, Y., Wu, X., Shih, P.-Y., Liao, C.-S., Bungart, B., Xu, X.-M., Drenan, R.M., Bartlett, E., and Cheng, J.-X. (2017) Label-free vibrational spectroscopic imaging of neuronal membrane potential. J. Phys. Chem. Lett. 8: 1932-36.


Shih, P-Y., McIntosh, J.M., and *Drenan R.M. (2015) Nicotine dependence reveals distinct responses from neurons and their resident nicotinic receptors in medial habenula. Mol. Pharmacol. 88: 1035-44. *corresponding author

Berry, J.B., Engle, S.E., McIntosh, J.M., and *Drenan, R.M. (2015) a6-containing nicotinic acetylcholine receptors in midbrain dopamine neurons are poised to govern dopamine-mediated behaviors and synaptic plasticity. Neuroscience 304: 161-175. *corresponding author

Wieskopf, J.S., Mathur, J., Limapichat, W., Post, M.R., Al-Qazzaz, M., Sorge, R.E., Martin, L.J., Zaykin, D.V., Smith, S.B., Freitas, K., Austin, J-S., Dai, F., Zhang, J., Marcovitz, J., Tuttle, A.H., Slepian, P.M., Clarke, S., Drenan, R.M., Janes, J., Al Sharari, S., Segall, S.K., Aasvang, E.K., Lai, W., Bittner, R., Richards, C.I., Slade, G.D., Kehlet, H., Walker, J., Maskos, U., Changeux, J-P., Devor, M., Maixner, W., Diatchenko, L., Belfer, I., Dougherty, D.A., Su, A.I., Lummis, S.C.R., Damaj, M.I., Lester, H.A., Patapoutian, A., and Mogil, J.S. (2015) The nicotinic a6 subunit gene determines variability in chronic pain sensitivity via cross-inhibition of P2X2/3 receptors. Sci. Transl. Med. 7(287): 287ra72.

Bordia, T., McGregor, M., McIntosh, J.M., Drenan, R.M., and Quik, M. (2015) Evidence for a role for a6* nAChRs in L-dopa-induced dyskinesias using parkinsonian a6* nAChR gain-of-function mice. Neuroscience 295: 187-197.


Engle, S.E., McIntosh, J.M., and *Drenan, R.M. (2014) Nicotine and ethanol cooperate to enhance ventral tegmental area AMPA receptor function via a6-containing nicotinic receptors. Neuropharmacology 91: 13-22. *corresponding author

Shih, P-Y., Engle, S.E., Oh, G., Deshpande, P., Puskar, N.L., Lester, H.A., and *Drenan, R.M. (2014) Differential expression and function of nicotinic acetylcholine receptors in subdivisions of medial habenula. J. Neurosci. 34(29): 9789-802. *corresponding author


Wang, Y., Lee, J.-W., Oh, G., Grady, S.R., McIntosh, J.M., Brunzell, D.H., Cannon, J.R., and *Drenan, R.M. (2013) Enhanced synthesis and release of dopamine in transgenic mice with gain-of-function a6* nAChRs. J. Neurochem. 129(2): 315-27. *corresponding author

Henderson, B.J., Srinivasan, R., Nichols, W.A., Dilworth, C.N., Gutierrez, D.F., Mackey, E.D.W., McKinney, S., Drenan, R.M., Richards, C.I., and Lester, H.A. (2013) Nicotine exploits a COPI-mediated process for chaperone-mediated upregulation of its receptors. J. Gen. Physiol. 143(1): 51-66.

Engle, S.E., Shih, P-Y., McIntosh, J.M., and *Drenan, R.M. (2013) a4a6b2* nAChR activation on VTA DA neurons is sufficient to stimulate a depolarizing conductance and enhance surface AMPA receptor function. Mol. Pharmacol. 84(3): 393-406. *corresponding author

Powers, M.S., Broderick, H.J., *Drenan, R.M., and *Chester, J.A. (2013) Nicotinic acetylcholine receptors containing a6 subunits contribute to alcohol reward-related behaviors. Genes Brain Behav. 12(5): 543-553. *co-corresponding author


Engle, S.E., Broderick, H.J., and *Drenan, R.M. (2012) Local application of drugs to study nicotinic acetylcholine receptor function in mouse brain slices. J. Vis. Exp. (68), e50034, doi: 10.3791/50034. *corresponding author

*Drenan, R.M., and Lester, H.A. (2012) Neurobiology of the cholinergic system and nicotine probed with mice expressing gain-of-function nAChR subunits. Pharmacological Reviews 64(4): 869-79. *corresponding author

Mackey, E.D.W., Engle, S.E., Kim, M., O’Neill, H.C., Wageman, C.R., Patzlaff, N.E., Wang, Y., Grady, S.R., McIntosh, J.M., Marks, M.J., Lester, H.A., and *Drenan, R.M. (2012) a6* nicotinic acetylcholine receptor expression and function in a visual salience circuit. J. Neurosci. 32(30): 10226-10237. *corresponding author

Cohen, B.N., Mackey, E.D.W., Grady, S.R., McKinney, S., Patzlaff, N.E., Wageman, C.R., McIntosh, J.M., Marks, M.J., Lester, H.A., and *Drenan, R.M. (2012) Nicotinic cholinergic mechanisms causing elevated dopamine release and abnormal locomotor behavior. Neuroscience 200: 31-41. *corresponding author


Xiao, C., Srinivasan, R., Drenan, R.M., Mackey, E.D., McIntosh, J.M., and Lester, H.A. (2011) Characterizing functional α6β2 nicotinic acetylcholine receptors in vitro: Mutant β2 subunits improve membrane expression, and fluorescent proteins reveal responsive cells. Biochemical Pharmacology 82(8):852-61.


Gunapala, K.M., Chang, D., Hsu, C.T., Manaye, K., Drenan, R.M., Switzer, R.C., and Steele, A.D. (2010) Striatal pathology underlies prion infection-mediated hyperactivity in mice.  Prion 4(4): 1-14.

Drenan, R.M., Grady, S.R., Steele, A.D., McKinney, S., Patzlaff, N.E., McIntosh, J.M., Marks, M.J., Miwa, J., and Lester, H.A. (2010) Cholinergic modulation of locomotion and striatal dopamine release is mediated by a6a4* nicotinic acetylcholine receptors.  J. Neurosci. 30(29): 9877-9889.

Grady, S.R., Drenan, R.M., Breining, S.R., Yohannes, D., Wageman, C.R., Fedorov, N.B., McKinney, S., Whiteaker, P., Bencherif, M., Lester, H.A., and Marks, M.J. (2010) Structural differences determine the relative selectivity of nicotinic compounds for native a4b2*, a6b2*, a3b4*, and a7 nicotinic acetylcholine receptors.  Neuropharmacology 58(7): 1054-66.


Drenan, R.M., Grady, S.R., Whiteaker, P., McClure-Begley, T., McKinney, S., Miwa, J., Bupp, S., Heintz, N., McIntosh, J.M., Bencherif, M., Marks, M.J., and Lester, H.A. (2008) In vivo activation of midbrain dopamine neurons via sensitized, high-affinity a6* nicotinic acetylcholine receptors.  Neuron 60(1): 123-136.

Drenan, R.M., Nashmi, R., Imoukhuede, P., Just, H., McKinney, S.L., and Lester, H.A. (2008) Subcellular trafficking, pentameric assembly and subunit stoichiometry of neuronal nicotinic ACh receptors containing fluorescently-labeled a6 and b3 subunits.  Mol. Pharmacol. 73(1): 27-41.